Trained as a Herpatologist (study of reptiles-poisonous snakes-vipers at Jungle Operations Training Center, Canal Zone, School of The Americas. All Vipers are Neuro-toxic affecting nerve sytems including paralyisis and organ failure if no antivenom antidote given.
Snake venom-related enzyme underlies COVID-19 mortality
Published in The Journal of Clinical Investigation, has identified a snake venom-related enzyme that may be the key cause of COVID-19 related mortality. Their findings have revealed a brand-new target for potential therapeutic treatments.
- The role of lipid metabolism in COVID-19
- Up to 80% of individuals infected with SARS-CoV-2 are asymptomatic or develop mild to moderate symptoms. However, COVID-19 can be life-altering and ultimately fatal for the remaining 20%, with multiple organ failure often leading to mortality. Consequently, there is an urgent need to identify the cellular and molecular mechanisms responsible for severe COVID-19.
- Recent studies have suggested that lipid metabolism plays a key role in determining an individual’s response to COVID-19 infection. There is evidence that SARS-CoV-2 modifies the levels of various lipids in host cells. This indicates that severe COVID-19 may be accompanied by phospholipases that cleave intact phospholipids from cellular membranes.
- The team behind this study investigated this theory by using lipidomic methods to analyse blood samples. Samples were taken from individuals with no disease, mild COVID-19 and severe COVID-19 as well as deceased COVID-19 patients.
- Identification of key enzyme
- The analyses showed that deceased COVID-19 patients had the most significant changes to their lipid profile. In total, 181 unique molecules were identified in these patients, many of which were associated with phospholipid metabolism.
- Further targeted lipidomics revealed that in comparison to survivors, deceased patients had elevated levels of a circulating, catalytically active enzyme called secreted phospholipase A2 Group IIA (sPLA2-IIA). Their sPLA2-IIA levels were 9.6-fold higher than in mild patients and 5-fold higher than in severe patients. In addition, high sPLA2-IIA levels were significantly associated with multiple organ dysfunction. This implies that sPLA2-IIA may drive the organ failure seen in fatal COVID-19 cases.
- The study further demonstrated the importance of sPLA2-IIA through the use of a machine learning method. Out of 80 clinical indices, the algorithm identified sPLA2-IIA level as the key feature that differentiated survivors from non-survivors. This highlights a potential method for identifying COVID-19 patients at high risk of mortality.
- Here is ingredients fom current flu shots and it is in Covid Vaccinations as a Pastor friend demanded to see and by law theyhad to gave him a copy. *See 4th ingredient fron 1st.
- Eugenics is the scientifically inaccurate theory that humans can be improved through selective breeding of populations.
- Eugenicists believed in a prejudiced and incorrect understanding of Mendelian genetics that claimed abstract human qualities (e.g., intelligence and social behaviors) were inherited in a simple fashion. Similarly, they believed complex diseases and disorders were solely the outcome of genetic inheritance.
- The implementation of eugenics practices has caused widespread harm, particularly to populations that are being marginalized.
- Eugenics is not a fringe movement. Starting in the late 1800s, leaders and intellectuals worldwide perpetuated eugenic beliefs and policies based on common racist and xenophobic attitudes. Many of these beliefs and policies still exist in the United States.
- The genomics communities continue to work to scientifically debunk eugenic myths and combat modern-day manifestations of eugenics and scientific racism, particularly as they affect people of color, people with disabilities and LGBTQ+ individuals.
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